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May patients receiving 5-alpha-reductase inhibitors be in higher risk of COVID-19 complications?
Adamowicz, Jan; Juszczak, Kajetan; Drewa, Tomasz.
Med Hypotheses ; 140: 109751, 2020 Jul.
Article in English | MEDLINE | ID: covidwho-102029

ABSTRACT

COVID-19 pandemic is a major challenge for global and national healthcare providers. Number of new cases is continuously increasing with an emerging trend showing worse prognosis in males in comparison to females. Based on this observation, our proposed hypothesis is that 5-alpha-reductase inhibitors, that are commonly used for BPH treatment, may be one of the factors contributing to poorer prognosis in males.


Subject(s)
5-alpha Reductase Inhibitors/adverse effects , Coronavirus Infections/complications , Pneumonia, Viral/complications , Animals , Betacoronavirus , COVID-19 , Finasteride/adverse effects , Humans , Lung/drug effects , Lung/embryology , Male , Pandemics , Prognosis , Prostatic Hyperplasia/complications , Prostatic Hyperplasia/drug therapy , Respiratory Mucosa/drug effects , Respiratory Mucosa/embryology , SARS-CoV-2 , Sex Factors
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